Invited Speakers
  • Keishi Fujio
    The Univ. of Tokyo
    Japan
  • Dr. Fujio is a professor of Rheumatology, and his research focuses on elucidating the pathology of rheumatic diseases through functional genomic analysis. He has a broad background in rheumatology, with specific training and expertise in rheumatology and immunological research. As PI or co-Investigator on several grants funded by Japanese government, he laid the groundwork for the research by developing combination of clinical cohort and functional genome analysis over time as documented in the following publications. He constructed a large functional genome database named ImmuNexUT, which consists of transcriptome of bulk-sorted 28 immune cells from more than 500 patients with immune-mediated diseases. ImmuNexUT enabled us to identify immunological pathways associated with prognosis of disease. Specifically, the identification of the Disease-activity signature, IGHV4-34 in B cells, and ThA cell could significantly contribute to the optimization of therapy. He has also been working toward the realization of stratified medicine in rheumatoid arthritis and, through single-cell RNA sequencing of synovial biopsy specimens from 53 patients, identified a fibroblast subset associated with resistance to anti-cytokine therapy.
    Research & Clinical Focus

    Rheumatic Diseases

    Systemic lupus erythematosus

    Rheumatoid Arthritis

    Clinical Immunology

    Functional Genomics

    • Date Time Room Session Title Lecture Title
    May 16 10:30-11:00 Room 1 (3F) International Symposium 4 (KCR-JCR Research Committee)_Translating Genetic Epidemiology into Clinical Rheumatology Mapping Genetic Architecture of Autoimmune Rheumatic Diseases: From GWAS Discoveries to Mechanistic Insights